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The Food and Drug Administration, FDA, has approved the drug Vivitrol to the treatment of opioid dependence based on a news release by them on 10-12-2010.

Using two separate drugs to shed weight can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err on the side of caution and allow the FDA do its job and demand some research be done so the public recognizes the side effects and risks of the medications before we drive them. Keep in mind that drug companies will be in business to make money and that they would say almost anything to keep people on their medications.

Researchers found that participants using this drug for a year, lost excess weight within a month and have kept the extra weight off through the 56 weeks with the study. Contrave is often a combination of the drugs naltrexone and bupropion, which appears to reflect a fresh trend of weight-loss drugs that are made up of multiple active ingredient, which may make them more effective and safer.

Combo-pilling will be the newest fad or also the newest to come under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular is the fact that since right now there are no long term prescription slimming capsules that have been authorized by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug also can raise blood pressure and pulse rate, and must not be used in those with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heartrate and must not used in patients with uncontrolled high blood pressure, as well as by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.


Approving a drug with this particular many potentially lethal negative effects is inconsistent with all the mission statement with the FDA. The power from the drug manufacturing lobby is blatantly evident in the approval of numerous drugs requiring 'post-marketing' studies which might be clearly significant to overall drug safety inside the US.
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