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Contrave is looking very promising for those seeking an eating plan pill that actually works. The U.S. Food and Drug Administration reviewed Contrave on December 7, and approved the drug 13-7, stating the advantages of the drug outweighs the risk of a possible surge in blood pressure.

Using two separate drugs to lose weight naturally can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people who go through it you should err on the side of caution and allow the FDA do its job and demand some research be done in order that the public knows the side effects and hazards of the medications before we drive them. Keep in mind that drug companies come in business to generate income and that they would say almost anything to keep people on their own medications.

Researchers found that participants taking this drug for a year, lost weight within a month and have kept the weight off during the entire 56 weeks with the study. Contrave is a combination in the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, which may make them more effective and safer.

Combo-pilling is the newest fad or better yet the newest in the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular is the fact that since right now there are no long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug also can raise hypertension and pulse rate, and shouldn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high blood pressure levels, in addition to by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.


Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone will result in instant withdrawal. When suboxone is utilized correctly, the naloxone is destroyed in the liver shortly after uptake in the intestines and has no therapeutic effect. Buprenorphine may be the active substance; it can be absorbed within the tongue (and throughout the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who may have had gastric bypass, the location where the first the main intestine is bypassed and the stomach contents empty into a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy the place that the drug is taken up from the duodenum and transferred right to the liver with the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be adopted by portions of the intestine which aren't served by the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.